Cholangiocarcinoma (CCA) is an aggressive malignancy originating from the epithelium lining of the biliary tree and can be divided into two main classes in accordance with the anatomical and cellular origin: intrahepatic Cholangiocarcinoma (iCCA) and extrahepatic Cholangiocarcinoma (eCCA). It is characterized by a steady increase in incidence globally with a median survival of fewer than […]
Gallbladder Cancer Symptoms: Prominent Risk Factors In India Cancer of the gallbladder is relatively rare in India; however, it still contributes to about 10% of the global GBC burden. A vast majority of the gallbladder cancer cases are diagnosed in the advanced stages of disease (stage III and above) resulting in poor clinical outcomes. The […]
Cervical Cancer, cancer that is initiated in the cervix. Cervix a part of a female reproductive organ that connects the vagina, a birth canal, to the upper region of the uterus, a womb where a baby grows during pregnancy. Cancer, considered as a disease in which cells of the body grow and divide abnormally, in […]
Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women. As per The American Cancer Society, the lifetime risk of developing colorectal cancer is about 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women. This risk is slightly lower in women […]
When a BRCA gene is mutated, it may no longer be effective at homologous recombination (HR) DNA repair machinery. Thus people with a BRCA gene mutation are more likely to develop cancer at a younger age. In these tumors, the base excision repair pathway is important for cell survival. The poly(adenosine diphosphate-ribose) polymerase (PARP) enzymes […]
