The name “BRCA” is an abbreviation for “BReast CAncer gene.”. BRCA1 and BRCA2 are two different genes that have been found to impact a person’s chances of developing breast cancer. Every human has both the BRCA1 and BRCA2 genes.
People with a mutation in either the BRCA gene (also know as BRCA1/2) have risks of up to 87 percent for developing breast cancer and 39-63 percent for developing ovarian cancer by age 70.
When a BRCA gene is mutated, it may no longer be effective at homologous recombination (HR) DNA repair machinery. Thus people with a BRCA gene mutation are more likely to develop cancer at a younger age. In these tumors, the base excision repair pathway is important for cell survival. The poly(adenosine diphosphate-ribose) polymerase (PARP) enzymes […]
PARP Inhibitors: Progressively Accurate class of Response Polymerases and their role in Neoadjuvant setting PARP (Poly-adenosine diphosphate (ADP) ribose polymerase) are nucleoproteins that mediate the transfer of ADP ribose group to an adaptor protein, therefore, helping to generate long poly (ADP ribose) chains. Post this modification, these nucleoproteins are known to mediate several cellular functions […]
The treatments for ovarian cancer have been developed and been developing for decades. Ovarian cancer standard treatment is surgery or chemotherapy. Although advanced ovarian cancer and high grade serous ovarian cancer are considered treating with targeted therapy, hormonal therapy. Treatment plans for ovarian cancer depend on factors such as: The location of the cancer How […]
Is Cancer Genetic? What causes Cancer? Certain changes in the genes called mutations, alters the cell growth and function. We know that genes code for proteins and once the gene coding is altered the protein formed is altered too. Now the next question that would come to your mind is, that if mutations are changes […]
Is Cancer Hereditary? What is hereditary? The characteristic of a disease, determined by genetic factors that are passed on from parents to their offspring. So is cancer hereditary? Cancer is a disease caused due to change or alteration in genes also called mutations or genetic mutations. These genetic mutations can be acquired mutations or inherited […]